Table 2.
Morphometric and haemodynamic parameters 4 weeks after LAD ligation or sham surgery
| Sham | Vehicle | KR36676 (30 mg·kg−1) | |
|---|---|---|---|
| n | 15 | 16 | 15 |
| BW (before, g) | 273.1 ± 4.5 | 265.4 ± 3.9 | 268.3 ± 4.5 |
| BW (after, g) | 435.6 ± 8.5 | 408.2 ± 7.3 | 392.3 ± 6.1 |
| RA/BW (mg·g−1) | 0.068 ± 0.003 | 0.085 ± 0.006 | 0.082 ± 0.005 |
| LA/BW (mg·g−1) | 0.071 ± 0.003 | 0.076 ± 0.003 | 0.071 ± 0.004 |
| RV/BW (mg·g−1) | 0.491 ± 0.011 | 0.507 ± 0.012 | 0.528 ± 0.012 |
| (LV+S)/BW (mg·g−1) | 1.792 ± 0.031 | 1.992 ± 0.041 | 2.010 ± 0.046 |
| Lung/BW (mg·g−1) | 2.638 ± 0.053 | 2.725 ± 0.046 | 2.724 ± 0.063 |
| Infarct size (%) | 0 ± 0 | 27.9 ± 4.3 | 21.3 ± 4.3 |
| Expansion index | 0 ± 0 | 0.778 ± 0.118 | 0.471 ± 0.087# |
| HR (beats·per min) | 416.1 ± 7.2 | 422.2 ± 7.8 | 447.7 ± 8.4 |
| LVSP (mmHg) | 133.9 ± 1.9 | 130.1 ± 2.9 | 145.0 ± 3.7 |
| LVEDP (mmHg) | 7.4 ± 0.6 | 7.8 ± 0.6 | 7.3 ± 0.4 |
| SV (μL) | 104.8 ± 5.1 | 79.8 ± 8.2 | 91.1 ± 10.0 |
| CO (mL·min−1) | 43.5 ± 2.1 | 33.7 ± 3.5 | 41.0 ± 4.7 |
| EF (%) | 59.3 ± 4.2 | 36.5 ± 3.7* | 43.2 ± 6.0 |
| SW (mmHg·mL) | 9.7 ± 0.5 | 6.9 ± 0.8* | 8.3 ± 0.8 |
| +dP/dtmax (mmHg·s−1) | 9539.8 ± 284.4 | 8706.3 ± 333.7 | 10 154.6 ± 5 559.4# |
| −dP/dtmax (mmHg·s−1) | −11 406.7 ± 539.3 | −9001.4 ± 502.9* | −11 197.7 ± 717.7# |
BW, body weight; CO, cardiac output; EF, ejection fraction; HR, heart rate; LA, left atrium; LV dP/dtmax, positive (+dP/dt) and negative (−dP/dt) maximum rate of pressure in left ventricle; LV+S, left ventricle plus septum; LVEDP, left ventricular end-diastolic pressure; LVSP, left ventricular systolic pressure; RA, right atrium; RV, right ventricle; SV, stroke volume; SW, stroke work. Data were expressed as mean ± SEM.
*
P < 0.05, significantly different from the sham group.
#
P < 0.05, significantly different from the vehicle-treated group.