Table 2.

Effect of a maximally effective concentration of indacaterol on the potency and intrinsic activity values of a panel of glucocorticoid receptor ligands to promote GRE-dependent transcription in BEAS-2B reporter cells

Glucocorticoid	n	p[A]50 −Indacaterol	Fold induction −Indacaterol	αa	p[A]50 +Indacaterol	Fold Induction +Indacaterolb	αa
Fluticasone furoate	4	8.73 ± 0.05	16.4 ± 0.80	1	8.66 ± 0.08	44.1 ± 3.30	1.00
Dexamethasone	4	7.79 ± 0.07	14.9 ± 0.46	0.96	7.80 ± 0.06	41.7 ± 2.54	0.94
GSK 9027	5	6.77 ± 0.17	12.8 ± 2.10	0.77	7.03 ± 0.05	30.1 ± 2.73	0.68
Des-ciclesonide	5	8.39 ± 0.03	9.22 ± 0.24	0.53	8.32 ± 0.05	25.5 ± 1.15	0.57
GW 870086X	8	7.72 ± 0.05	6.67 ± 0.22	0.36	7.72 ± 0.04	14.3 ± 0.67	0.31
Mifepristone	8	7.67 ± 0.42	1.26 ± 0.09	0.02	7.75 ± 0.16	1.81 ± 0.06	0.02
Org 34517	6	Inactive	0.99b	0	8.02b	1.24b	0.006

Values were calculated from the data shown in Figures 1A–F and 3A using indacaterol at a concentration of 100 nM.

^aIntrinsic activity (fold induction by GR ligand − 1)/(fold induction by FF − 1).

^bValues determined from pooled data.