. 2015 Mar 24;172(10):2634–2653. doi: 10.1111/bph.13087

Table 5.

Effect of indacaterol and forskolin on the affinity of Org 34517 for GR

GR agonist	pK_B	pK_B + Forskolin	pK_B + Indacaterol
Fluticasone furoate	8.34^a	8.36	ND
Dexamethasone	8.38^a	8.35	8.39^b
Des-ciclesonide	8.12^a	8.39	ND
GW 870086X	8.46^a	8.38	ND

The affinity of the GR antagonist, Org 34517, was calculated by Schild analysis from the data shown in Supporting Information Fig. S4. Indacaterol and forskolin were used at concentrations of 100 nM and 10 μM respectively.

Data taken from Joshi et al. (2015).

pA₂ value determined using Org 34517 at 10 and 100 nM.

ND, not determined.