Table 3. Diagnostic performance of DCE-MRI, DWI, DTI and combination diagnosis in differential diagnosis between DCIS and IBC.
| Parameter | AUC (95% CI) | P* | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|
| DCE-MRI | 0.84 (0.73-0.92) | – | 92.5 (49/53) | 72.7 (8/11) | 94.2 (49/52) | 66.7 (8/12) | 89.1 (57/64) |
| ADC (DWI) | 0.83 (0.72-0.92) | 0.955 | 75.5 (40/53) | 81.8 (9/11) | 95.2 (40/42) | 40.9 (9/22) | 76.6 (49/64) |
| EA (DTI) | 0.91 (0.81-0.97) | 0.257 | 81.1 (43/53) | 90.9 (10/11) | 97.7 (43/44) | 50.0 (10/20) | 82.8 (53/64) |
| DCE+DTI | 0.94 (0.85-0.99) | 0.020 | 96.2 (51/53) | 72.7 (8/11) | 94.4 (51/54) | 80.0 (8/10) | 92.2 (59/64) |
*, compared with DCE-MRI. Abbreviations: DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; DWI, diffusion weighted imaging; DTI, diffusion-tensor imaging; DCIS, breast ductal carcinoma in situ; IBC, invasive breast carcinoma; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; ADC, apparent diffusion coefficient; EA, exponential attenuation.