Table 4.

Estimates of aggregate desaturase indices (ADI) according to genotype for each SNP in Caucasian females

	n-3 ADI (EPA:ALA)							n-6 ADI (AA:LA)
	MM		Mm		mm		p-value	MM		Mm		mm		p-value
	ADI	SEM	ADI	SEM	ADI	SEM		ADI	SEM	ADI	SEM	ADI	SEM
FADS1
rs174547	0.987a	0.063	0.972a,b	0.053	0.533b	0.095	0.6 × 10−3	0.225a	0.004	0.189b	0.004	0.156c	0.006	1.00 × 10−16*
rs412334	0.861	0.048	0.821	0.069	0.732	0.098	0.43	0.197b	0.004	0.209a,b	0.006	0.243a	0.012	0.01
FADS2
rs174570	0.886	0.044	0.769	0.082	0.428	0.046	0.09	0.212a	0.003	0.176b	0.006	0.133b	0.005	9.02 × 10−11*
rs174576	0.999a	0.064	0.791b	0.052	0.526b	0.092	0.4 × 10−3	0.226a	0.004	0.190b	0.004	0.156c	0.006	7.33 × 10−17*
rs174579	0.938a	0.054	0.686b	0.044	0.757a,b	0.196	4.2 × 10−3	0.211a	0.004	0.185b	0.005	0.184a,b	0.014	0.0001*
rs174593	0.910	0.054	0.797	0.061	0.677	0.125	0.04	0.213a	0.004	0.191b	0.004	0.166b	0.007	6.99 × 10−6*
rs174602	0.835	0.041	0.883	0.079	0.762	0.189	0.79	0.204a	0.004	0.202a	0.005	0.162b	0.008	7.40 × 10−3
rs174611	0.941	0.060	0.760	0.053	0.708	0.101	0.13	0.213a	0.004	0.189b	0.005	0.184b	0.010	9.32 × 10−5*
rs174626	1.001a	0.084	0.847a,b	0.053	0.691b	0.070	2.9 × 10−3	0.219a	0.007	0.202a	0.004	0.182b	0.006	1.47 × 10−5*
rs174627	0.895	0.046	0.747	0.076	0.474	0.061	8.7 × 10−3	0.207a	0.004	0.188b	0.006	0.157b	0.014	2.40 × 10−3
rs17831757	0.873	0.047	0.763	0.063	0.795	0.130	0.75	0.204	0.003	0.189	0.007	0.221	0.024	0.02
rs2072114	0.885	0.043	0.778	0.091	0.387	0.042	0.06	0.210a	0.003	0.180b	0.006	0.143b	0.008	1.23 × 10−8*
rs2845573	0.873	0.041	0.749	0.113	0.428	0.046	0.28	0.207a	0.003	0.172b	0.007	0.133b	0.005	1.58 × 10−7*
rs2851682	0.876	0.042	0.748	0.102	0.428	0.046	0.32	0.207a	0.003	0.177b	0.007	0.133b	0.005	1.65 × 10−6*
rs482548	0.840	0.044	0.879	0.081	0.989	0.356	0.64	0.198	0.003	0.215	0.007	0.197	0.022	0.05
rs498793	0.812	0.074	0.890	0.053	0.771	0.081	0.64	0.191	0.006	0.206	0.004	0.204	0.008	0.51
rs526126	0.873	0.049	0.823	0.070	0.653	0.086	0.57	0.205	0.004	0.192	0.005	0.195	0.014	0.09
rs968567	0.927a	0.051	0.687b	0.051	0.487a,b	0.079	0.02	0.209a	0.004	0.186b	0.004	0.168a,b	0.021	0.70 × 10−3

Results of analysis of 18 SNP from the FADS cluster for associations with n-3 and n-6 ADI. Different letters (^a, ^b or ^c) denote values that are significantly different between groups. The * denotes p-values which are significant and withstood multiple testing. P-values were determined using multiple linear regression models which were adjusted for BMI, age, dietary LA, ALA, EPA and DHA, % total energy from dietary fat and physical activity. Abbreviations: M major, m minor, ADI aggregate desaturase indices, SEM standard error of the mean.