Table 2.
Strain dependence of specific proportions of GAGs retained within collagen gels seeded with leaflet or chordal cells.
Unconstrained | Statically constrained | Cyclic 2% | Cyclic 5% | Cyclic 10% | ||
---|---|---|---|---|---|---|
Leaflet | % HA | 12.6±0.7 | 11.3±1.4† | 24.7±8.7* | 19.3±8.4* | 15.0±2.7* |
% 6-S | 14.3±2.0* | 11.8±2.5* | 12.0±4.1* | 11.0±1.2 y | 13.1±1.4 y | |
% 4-S | 73.1±1.3 | 77.0±4.0† | 63.4±6.6* | 69.7±9.5* | 71.9±1.7*x | |
Chordae | % HA | 12.4±0.7 | 11.6±1.5 | 4.9±4.0 | 4.0±1.6 | 2.6±0.5 |
% 6-S | 18.4±1.1 | 18.4±1.1 | 18.8±1.8 | 13.7±1.3†‡y | 14.0±1.7†‡ y | |
% 4-S | 66.6±0.2 | 70.0±0.5φ | 76.3±4.5 | 82.3±1.5‡ | 83.4±1.7‡x |
Data are mean percentage ± standard deviation.
p<0.007 vs. chordae,
p<0.04 vs. 2%,
p<0.01 vs. unconstrained,
p<0.03 vs. 10%.
When leaflet and chordal data were grouped together,
p<0.02 vs. 2%,
p<0.04 vs. unconstrained.