Table 3.

Strain dependence of total GAGs (nmol), ratio of 4-S to 6-S, and ratio of S-GAGs to HA calculated from amounts of GAGs secreted into the medium surrounding collagen gels seeded with leaflet or chordal cells.

		Unconstrained	Statically constrained	Cyclic 2%	Cyclic 5%	Cyclic 10%
Leaflet	Total GAGs (nmol)	92.4±7.7* x	125.2±10.6	174.7±48.0†	131.4±37.1†	86.4±12.0*†
	4-S/6-S	3.2±0.1y	3.1±0.1y	3.9±0.2	3.9±0.2	3.4±0.4
	S-GAGs/HA	0.7±0.2	0.9±0.5†	1.0±0.2	1.0±0.2	0.7±0.1†
Chordae	Total GAGs (nmol)	65.2±19.5φx	83.6±17.5	84.8±20.1	90.2±10.9	137.6±19.8
	4-S/6-S	3.0±0.3y	2.6±0.0y	3.5±0.7	4.0±1.3	3.5±0.4
	S-GAGs/HA	1.0±0.5	1.6±0.4	1.1±0.2	1.4±0.3	1.3±0.6

Data are mean ± standard deviation.

^*p<0.02 vs. 2%,

^φp<0.04 vs. 10%,

^†p<0.05 vs. chordae.

When leaflet and chordal data were grouped together,

^xp<0.04 vs. 2%,

^yp<0.03 vs. 5%.