Table 2.
Summary chart of histologic and hematologic data for each patients
| Patient (age, gender) |
Time (PTD) |
C4d intensity |
C4d site |
CD 138 intensity |
Banff score |
Hgb (g/dL) |
WBC (1000/lL) |
Plt (1000/lL) |
Treatment |
|---|---|---|---|---|---|---|---|---|---|
| Patient 1 (62 year, F) |
8 15 |
+11 +11 |
Portal venules1 Portal venules1 |
+21 +21 |
II II |
11.6 9.7 |
13.1 14.3 |
319 590 |
Steroids OKT-3 |
| 31 | +11 | Portal venules1 | +21 | III | 10.0 | 8.0 | 127 | Thymoglobulin | |
| 41 | +21 | Portal venules1 | +31 | II | 10.1 | 9.4 | 130 | Steroids | |
| 52 | +3 | Portal venules | +3 | II | 9.6 | 6.5 | 204 | Bortezomib | |
| 84 | 0 | N/A | 0 | 0 | 11.0 | 3.9 | 169 | – | |
| 361 | 0 | N/A | 0 | 0 | 9.4 | 3.0 | 121 | – | |
| Patient 2 (28 year, F) |
452 459 |
+21 +21 |
Portal venules1 Portal venules1 |
+21 +31 |
III II |
13.8 12.7 |
3.5 5.3 |
265 347 |
Steroids Thymoglobulin |
| 469 | +2 | Portal venules | +3 | I | 13.2 | 3.7 | 304 | Rituximab | |
| 518 | +3 | Portal venules | +3 | I | 14.2 | 2.2 | 275 | Bortezomib | |
| 549 | 0 | N/A | 0 | 0 | 12.7 | 5.3 | 137 | ||
| 639 | 0 | N/A | 0 | 0 | 11.6 | 5.9 | 215 | PP + Bortezomib2 | |
| 909 | 0 | N/A | 0 | 0 | 13.4 | 7.5 | 285 | – | |
| Patient 3 (53 year, F) |
6 22 |
+31 +31 |
Portal venules1 Portal venules1 |
+31 +31 |
II I |
8.9 9.8 |
4.4 3.3 |
70 165 |
Increased prograf |
| 49 | +3 | Portal venules | +3 | I | 9.6 | 3.9 | 160 | Bortezomib | |
| 78 | 0 | N/A | 0 | 0 | 9.0 | 2.2 | 89 | – |
PTD = posttransplant day; Hgb = hemoglobin; WBC = white blood cell; Plt = platelets; y = years; F = female; N/A = not applicable; PP = plasmapheresis. stain intensity: 0 = negative; +1 = low; +2 = moderate; +3 = high.
1
Stains performed retrospectively after diagnosis of acute AMR.
2
Biopsy showed early ductopenia; LFTs and DSA were elevated.