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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Bioorg Med Chem. 2014 Sep 17;22(21):5917–5923. doi: 10.1016/j.bmc.2014.09.016

Figure 4.

Figure 4

Immunologic evaluation of saponin–tucaresol conjugate 10 (SQS-1-0-5-19), lacking the branched trisaccharide domain, with a three-component vaccine comprised of MUC1–KLH and OVA for (a) anti-KLH titers (IgG), (b) anti-MUC1 titers (IgG), and (c) anti-OVA titers (IgG). Data for the branched-trisaccharide containing conjugate 9 (SQS-0-0-5-19) is from the separate experiment shown in Figure 3, shown here for comparison. Horizontal bars indicate median titers; statistical significance compared to no-adjuvant negative control was assessed using two-tailed unpaired Student T-test with CI = 95%: * p ≤ 0.05, ** p < 0.01, *** p< 0.001. (d) Toxicity assessment based on median weight loss over one week after the first vaccine