Table 1.
Relative transfection of bioreducible PAA in a panel of pancreatic cancer cell line with increasing cellular GSH content.a (Adapted from [132])
| Nucleic acid | Cell line (GSH concentration) |
|||
|---|---|---|---|---|
| Panc-1 (1.1 mM) | MiaPaCa (2.4 mM) | AsPC-1 (4.7 mM) | Panc-28 (7.5 mM) | |
| Plasmid DNA | 0.9 | 3.2 | 5.4 | 0.1 |
| mRNA | 5.6 | 8.8 | 2.0 | 54 |
| siRNA | 0.7 | 1.0 | 0.9 | 0.8 |
| AON | 0.7 | 1.2 | 1.6 | 1.3 |
a
Values in the table were calculated by dividing transfections of polyplexes made with bioreducible PAA with transfections of non-bioreducible PAA polyplexes.