Table 1.

Inherited arrhythmia syndromes and their predominant genetic causes.

Condition	Predominant gene(s)*
Long QT syndrome	KCNQ1, KCNH2, SCN5A
Catecholaminergic polymorphic ventricular tachycardia	RYR2, CASQ
Brugada syndrome	SCN5A
Cardiac conduction system disease	SCN5A
Short QT syndrome	KCNH2, KCNQ1, KCNJ2
Hypertrophic cardiomyopathy	MYBPC3, MYH7, TNNI3, TNNT2, TPM1
Arrhythmogenic ventricular cardiomyopathy	DSC2, DSG2, DSP, JUP, PKP2, TMEM43
Dilated cardiomyopathy (with conduction system disease)	TTN, (LMNA, SCN5A)
Left ventricular noncompaction cardiomyopathy	LBD3
Restrictive cardiomyopathy	MYH7, TNNI3
Sudden unexplained death & sudden infant death syndrome	KCNQ1, KCNH2, SCN5A, RYR2
Atrial fibrillation	Predominant forms are polygenic

^*The reader is referred to other sources for comprehensive reviews on the genetic bases of these conditions. ^1-8