Table 5.
Biological validation of gene lists. Differentially expressed genes involved in heatshock response, DNA repair, and immune response for males and females.
| Gene symbol | Description | Fold change | ||
|---|---|---|---|---|
| Heat shock | ||||
| Males | ||||
| HSP1AB | heat shock 70kDa protein 1B | 1.055 | ||
| HSPBP1 | heat shock 70kDa biding protein, cytoplasmic chaperone 1 | 1.038 | ||
| HSF5 | heat shock transcription family member 5 | 1.036 | ||
| Females | ||||
| HSPA13 | heat shock 70kDa protein 13 | −1.054 | ||
| DNA repair | ||||
| Males | ||||
| RBBP8 | retinoblastoma binding protein 8 | 1.060 | ||
| CDK7 | cyclin-dependent kinase 7 | 1.058 | ||
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 1.036 | ||
| POLI | polymerase (DNA directed) iota), RPA3 (replication protein A3, 14kDa | −1.054 | ||
| RPA3 | replication protein A3, 14kDa | 1.030 | ||
| LIG3 | ligase III, DNA, ATP-dependent | −1.027 | ||
| Females | ||||
| RBBP8 | retinoblastoma binding protein 8 | −1.080 | ||
| MDC1 | mediator of DNA-damage checkpoint 1 | 1.041 | ||
| LIG4 | ligase IV, DNA, ATP-dependent | −1.060 | ||
| MSH2 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | −1.059 | ||
| SMUG1 | single-strand-selective monofunctional uracil-DNA glycosylase 1 | −1.069 | ||
| Immune system | ||||
| Males | ||||
| RSAD2 | S-adenosyl methionine domain containing protein 2 | 1.186 | ||
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 1.207 | ||
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 1.123 | ||
| IFIT5 | interferon-induced protein with tetratricopeptide repeats 5 | 1.095 | ||
| IFI44L | interferon-induced protein 44-like | 1.323 | ||
| IFI6 | interferon, alpha-inducible protein 6 | 1.201 | ||
| MX1 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 1.180 | ||
| IL23A | interleukin 23, alpha subunit p19 | −1.045 | ||
| IL11RA | interleukin 11 receptor, alpha | −1.046 | ||
| IL15RA | interleukin 5 receptor, alpha | −1.047 | ||
| IL1RL1 | interleukin 1 receptor-like 1 | −1.102 | ||
| IL1RN | interleukin 1 receptor antagonist | −1.084 | ||
| IL17C | interleukin 17C | −1.037 | ||
| Females | ||||
| IL11RA | interleukin 11 receptor, alpha | 1.103 | ||
| IL13RA1 | interleukin 13 receptor, alpha 1 | 1.089 | ||
| IL18BP | IL18 binding protein | 1.070 | ||
| IL16 | interleukin 16 | −1.035 | ||
| HLA-DRB6 | major histocompatibility complex, class II, DR beta 6 (psuedogene) | −1.083 | ||
| HLA-B | major histocompatibility complex, class I, B | −1.083 | ||
| HLA-G | major histocompatibility complex, class I, G | −1.129 | ||
| IFIH1 | interferon induced with helicase C domain 1 | −1.109 | ||