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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Cancer Lett. 2015 Mar 30;362(2):158–166. doi: 10.1016/j.canlet.2015.03.034

Figure 5. The MAPK/ERK pathway is involved in LANA-induced HA production from primary endothelial cells.

Figure 5

(A-C) HUVEC were transfected with control vector (pc), or vectors encoding LANA (pcLANA) at 0.2, 1.0 or 2.5 μg, respectively, for 48 h, then some cells were treated with vehicle, MAPK inhibitor U0126 (10 μM), or NF-κB inhibitor Bay11-7085 (10 μM) for 2 h followed by additional 24 h-culture. (D-E) Cells were infected with KSHV for 2 h, then treated with vehicle or signaling inhibitors as above. Protein expression, Has1 gene transcription and HA production were measured as above. Error bars represent the S.E.M. for three independent experiments. **=p<0.01.