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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Curr Top Med Chem. 2015;15(12):1138–1152. doi: 10.2174/1568026615666150413153400

Fig. (5).

Fig. (5)

(A) The schematic illustration of producing thrombin aptamer-crosslinked sequence (TACS) conjugated microbubbles for thrombin detection. The thrombin response curve was adapted with permission from reference [93]. (B) In vitro US imaging with TACS microbubbles in active blood clots. The existence of thrombin significantly enhanced the acoustic signals from TACS microbubbles. Adapted with permission from reference [93]. (C) In vivo US imaging of deep venous thrombosis in a rabbit model. Activation of TACS microbubbles was recorded at the clot site. Scrambled-aptamer crosslinking sequence (SACS) conjugated microbubbles were used as a control to confirm the thrombin specificity of TACS microbubbles. Adapted with permission from reference [94].