Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 11;91(3):76–91. doi: 10.2183/pjab.91.76

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Japan Academy

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — Schematic representation of arrest and resumption of first meiosis in mammalian oocytes. (A) Meiosis arresting factor (MAF) (●), located on the surface of and between granulosa cells, initiates meiotic arrest by acting directly on the cumulus–oocyte complex. (B) Gonadotropins stimulates the production and accumulation of ovarian glycosaminoglycans (oGAGs) that surround the cumulus–oocyte complex. oGAGs (○) in intercellular matrices prevent the action of MAF on the oocyte and interferes with the flow of MAF, promoting the resumption of meiosis.