Table 2.

Prevalence of Intermittent Claudication, Asymptomatic PAD, and Atypical Exertional Leg Symptoms in Defined Cohorts of People with Peripheral Artery Disease

Study/year of publication	Characteristics of PAD Population	Total Sample Size/Prevalence of PAD	Mean Age in Years (standard deviation)^*	Percent Female (%)	Prevalence of Claudication in PAD participants	Prevalence of Asymptomatic PAD	Prevalence of Atypical Exertional Leg Symptoms

Community Dwelling Populations
Lipid Research Clinics (1985) (29)	Community dwelling men and women in Southern California.	N=575 total/N=65 (11%) with PAD	66 Range 38–82	59%	N=6 (9.2%)	Not reported.	Not reported.
Cardiovascular Health Study (1993) (32)	Men and women age 65 and older from four United States Communities.	N=5,084 total/N=629 (12.4%) with ABI < 0.90	71.7 for those with ABI 0.90 to 1.50; 75.5 for those with ABI < 0.80.	:ABI < 0.80: 54.1% ABI 0.90 to 1.50: 60%	2.0% overall	Not reported.	Not reported.
Women’s Health and Aging Study (2000) (34)	Community dwelling women age 65 and older with disability and without leg pain.	N=933 N=328 (35%) with ABI < 0.90	PAD: 77.4 (7.3); Non-PAD: 75.5 (6.9)	100%	Not reported.	N=198 (60.3%)	Not reported.
Cardiovascular Health Study (2001) (33)	Men and women age 65 and older from four U.S. Communities.	N=5,888 overall N=723 with ABI < 0.90 (12%)	Range from 72.7 (5.5) in people without leg pain to 74.9 (5.8) in those with intermittent claudication.	54%	N= 62 (8.5%)	N=427 (59%)	N=234 (32%)

Primary Care Medical Practices
General Medicine Study (1999) (35)	Patients age 55 and older in a general medical practice with no prior history of PAD.	N=174 N=26 with PAD (14.9%)	PAD-69 (6.5) Non-PAD-68 (7.2)	PAD-31% Non-PAD-65%)	N=1 (3.8%)	N=14 (43.8%)	N=2 (7.7%)
PARTNERS Study (2001) (36)	Primary care patients who were a) age 70 and older or b) age 50 to 69 with history of smoking or diabetes.	N=6,979 overall N=1,865 (27%) with ABI < 0.90¹	68.9 (10) among those without PAD. Mean age of PAD ranged from 70.8 (10.1) to 72.3 (9.1).	52% overall	N=178 (9.5%)	N=572 (30.6%)	N=934 (50.1%)
Texas Primary Care Practices (37)	Patients age 50 and older in a Veterans Administration and two primary care practices in Houston.	N=403 total sample N=67 with PAD	Non-PAD: 63.5 (7.3). PAD: 65.3 (7.0)	Non-PAD: 53% PAD: 49%	N=5 (8%)	N=31 (47%)	N=30 (45%)
Get ABI Study (2009) (31)	Patients age 65 and older in primary care medical practices in Germany.	N=6,880 total sample size N=1,429 (21%) with PAD	Non-PAD: 72.2 + 5.1; PAD: 73.9 (5.6)	58%	N=593 (41.5%) had any symptoms or had history of peripheral revascularization or amputation.	N=836 (58.5%)	Not reported.

Non-invasive vascular laboratory
WALCS Chicago cohort (2001) (18)	Consecutive patients with PAD in a non-invasive vascular laboratory.	460 PAD participants	71.9 (8.4)	41%	N=150 (32%)	N=91 (20%)	N=219 (47.6%)

Standard deviation provided when available.