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The effect of 50 µM SB202190 (p38 MAPK inhibitor), 50 µM SP600125 (JNK inhibitor), 50 µM PD184352 (ERK inhibitor), 10 µM wortmannin (PI3 kinase inhibitor), and 5 µM EX-527 (SIRT-1 inhibitor) on 3-h serum deprivation-induced caspase 3 activation and the protective action of 200 µM resveratrol. Only p38 MAPK inhibitor SB202190 abolished the effect of resveratrol on caspase activation.
