Table IV. Dosing Guidelines for Narrowband UVB.
According to skin type: | |||
---|---|---|---|
Skin Type | Initial UVB dose (mJ/cm2) |
UVB Increase After Each Treatment (mJ/cm2) |
Maximum dose (mJ/cm2) |
I | 130 | 15 | 2000 |
II | 220 | 25 | 2000 |
III | 260 | 40 | 3000 |
IV | 330 | 45 | 3000 |
V | 350 | 60 | 5000 |
VI | 400 | 65 | 5000 |
According to MED: | |
---|---|
Initial UVB | 50% of MED |
Treatments 1 -20 | Increase by 10% of initial MED |
Treatment ≥ 21 | Increase as ordered by physician |
If subsequent treatments are missed for: | |
---|---|
4-7 d | Keep dose same |
1-2 wk | Decrease dose by 25% |
2-3 wk | Decrease dose by 50% or start over |
3-4 wk | Start over |
Maintenance therapy for NB-UVB after >95% clearance: | ||
---|---|---|
1×/ wk | NB-UVB for 4 wk | Keep dose same |
1×/ 2 wk | NB-UVB for 4 wk | Decrease dose by 25% |
1×/ 4 wk | NB-UVB | 50% of highest dose |
MED, Minimal erythema dose; NB, narrowband; UV, ultraviolet.
Administered 3-5×/wk.
Because there is broad range of MED for NB-UVB by skin type, MED testing is generally recommended. It is critically important to meter UVB machine once weekly. UVB lamps steadily lose power. If UV output is not periodically measured and actual output calibrated into machine, clinician may have false impression that patient can be treated with higher doses when machine is actually delivering much lower dose than number entered. Minimum frequency of phototherapy sessions required per week for successful maintenance as well as length of maintenance period varies tremendously between individuals. Above table represents most ideal situation where patient can taper off phototherapy. In reality, many patients require 1×/wk NB-UVB phototherapy indefinitely for successful long-term maintenance.
Reprinted from Journal of the American Academy of Dermatology, Volume 62, Menter A, Korman NJ, Elmets CA, Feldman SR, Gelfand JM, Gordon KB et al., Guidelines of care for the management of psoriasis and psoriatic arthritis. Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy, pages 114-135, Copyright 2010, with permission from the American Academy of Dermatology.