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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Nat Commun. 2015 Apr 24;6:6956. doi: 10.1038/ncomms7956

Figure 1. Proposed pathways lead to overproduction of CD4+CCR6+IL17A+.

Figure 1

(A). ET-BSP uptake by intestinal epithelial cells leads to induction of IDENCCL20+PGE2+S1P+. Due to increasing gut permeability or mucosa damage, released IDENCCL20+PGE2+SIP+ subsequently migrate into the peripheral blood and induce CCR6 expression on CD4 T cells, which results in more CD4+CCR6+IL17A+ cells being recruited into intestinal tissue. (B) Uptake of IDENCCL20+PGE2+S1P+ by intestinal macrophages results in induction of PGE2, which then promotes more production of CD4+CCR6+IL17A+.