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. 2015 Mar 30;21(5):499–508. doi: 10.1089/ten.tec.2014.0414

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Copyright 2015, Mary Ann Liebert, Inc.

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FIG. 1. — DFUFs and DFFs displayed altered cytokine secretion in vitro. Images of cytokine array membranes used to analyze secretion profiles of DFUF1, DFF6, and NFF10 are shown. Antibody spot locations are labeled: 1=CD40 Ligand, 2=CXCL1, 3=IFN-γ, 4=IL-6, 5=IL-8, 6=IL-23, 7=MCP-1, 8=MIF, 9=PAI-1, 10=SDF-1, RS=Reference spots, and NC=Negative control. Densitometric quantification of array spots normalized to cell number revealed that DFUF1 and DFF6 exhibit altered secretory profiles compared with NFF10 in 2D monolayer culture in vitro. CXCL1, C-X-C motif chemokine 1; DFFs, type II diabetic, nonulcerated foot-derived fibroblasts; DFUFs, type II diabetic foot ulcer-derived fibroblasts; IFN-γ, interferon gamma; IL, interleukin; MCP-1, monocyte chemotactic protein-1; MIF, macrophage migration inhibitory factor; PAI-1, plasminogen activator inhibitor-1; SDF-1, stromal-derived factor 1.