. 2015 Apr 1;9(2):95–103.

Table 1.

Probable anti-cancer mechanism of MSCs on different animal models of cancer- Summary of few in vivo experiments using different animal models of cancer indicating MSC source, type of animal model, mode of MSC infusion, observations and probable mechanism of action involved in tumor regression

Reference	Otsu 2009 ⁷⁰	Doi 2010 ⁷²	Cousin2009 ⁷⁹	Chanda 2009 ⁷³	Ren 2008 ⁵²
Observations	Otsu 2009 ⁷⁰	Doi 2010 ⁷²	Cousin2009 ⁷⁹	Chanda 2009 ⁷³	Ren 2008 ⁵²
Cancer	Melanoma	Pancreatic cancer	Pancreatic cancer	Prostate cancer	Prostate cancer
Cancer cell type	B16F10	PAN02	Capan-1	Osteolytic human prostate cancer cells PC3 expressing firefly luciferase	Mouse metastatic prostate cancer cell line TRAMP-C2
MSC source	Bone marrow	Umbilical Cord Tissue	Adipose tissue	Bone marrow	Bone marrow: Undifferentiated BMMSCs tranduced with 1000 MOI of rAAV6-IFN-β or rAAV6-GFP
Animal model	Subcutaneous graft in C57/BL mice	Orhtotopicxenograft in C57/BL mice	Subcutaneous xenograft in athymic nude mice	Male SCID mice with intratibial injection	Prostate cancer cells lung metastasis in male C57BL/6 mice
Mode of MSC infusion	IT injection	IP injection	IT injection	Intratibial injection	IV injection
Observations	Regression in tumor size	Regression of tumor size with enhancement in survival time	Regression in tumor size	Inhibition of tumor growth	Regression in tumor growth
Possible mode of action	Apoptosis induction and angiogenesis inhibition	Interference with proliferation and G0/G1 arrest	Interference with proliferation and G1 arrest	New bone formation around tumor cells in tibia restricted growth of prostate cancer cells	Tumor apoptosis, anti-angiogenesis and induction of NK cell activity