Table 1.
Reference |
Otsu 2009 70 | Doi 2010 72 | Cousin2009 79 | Chanda 2009 73 | Ren 2008 52 |
---|---|---|---|---|---|
Observations | |||||
Cancer | Melanoma | Pancreatic cancer | Pancreatic cancer | Prostate cancer | Prostate cancer |
Cancer cell type | B16F10 | PAN02 | Capan-1 | Osteolytic human prostate cancer cells PC3 expressing firefly luciferase | Mouse metastatic prostate cancer cell line TRAMP-C2 |
MSC source | Bone marrow | Umbilical Cord Tissue | Adipose tissue | Bone marrow | Bone marrow: Undifferentiated BMMSCs tranduced with 1000 MOI of rAAV6-IFN-β or rAAV6-GFP |
Animal model | Subcutaneous graft in C57/BL mice | Orhtotopicxenograft in C57/BL mice | Subcutaneous xenograft in athymic nude mice | Male SCID mice with intratibial injection | Prostate cancer cells lung metastasis in male C57BL/6 mice |
Mode of MSC infusion | IT injection | IP injection | IT injection | Intratibial injection | IV injection |
Observations | Regression in tumor size | Regression of tumor size with enhancement in survival time | Regression in tumor size | Inhibition of tumor growth | Regression in tumor growth |
Possible mode of action | Apoptosis induction and angiogenesis inhibition | Interference with proliferation and G0/G1 arrest | Interference with proliferation and G1 arrest | New bone formation around tumor cells in tibia restricted growth of prostate cancer cells | Tumor apoptosis, anti-angiogenesis and induction of NK cell activity |