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Heavy chain sequence homology with HIV bNMAbs. Alignment of germline VH and relevant HIV bNMAb. ○, common residue mutation location with HIV bNMAb; •, identical residue mutation with HIV bNMAb; *, HIV Env contact site of HIV bNMAb (4E10,(17) 10E8,(20) CH103(21)). Complementarity determining regions (CDR) are shaded.
