Table 2.
Molecular Characteristics of MAbs
| Heavy chain | Light chain | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subject | mAb | Selection Strategy | V | D | J | AA mutation (%) | CDR3 length (AA) | V | J | AA mutation (%) | CDR3 length (AA) |
| HIV018 | KS18-5 | gp140+IgD- | 3-15*05 | 3-22*01 | 5*02 | 27 | 13 | κ1-NL1*01 | κ4*01 | 20.9 | 9 |
| HIV037 | KS37-6 | gp140+9G4+ | 4-34*01 | 2-2*02 | 6*02 | 0 | 26 | λ9-49*01 | λ1*01 | 1 | 14 |
| HIV041 | KS41-2 | gp140+SCC | 4-4*02 | 1-20*01 | 6*02 | 17.3 | 20 | κ1-27*01 | κ1*01 | 7.7 | 9 |
| KS41-11 | gp140+SCC | 4-59*08 | 3-3*01 | 6*02 | 11.3 | 20 | κ3-20*01 | κ2*01 | 4.8 | 10 | |
| KS41-22 | gp140+SCC | 1-18*01 | 3-10*01 | 3*02 | 21.6 | 16 | κ1-27*01 | κ1*01 | 3.8 | 9 | |
| HIV059 | KS59-5 | gp140+IgG+ | 3-30*02 | 3-3*01 | 3*02 | 16.3 | 23 | κ2-30*02 | κ1*01 | 7.7 | 9 |
| KS59-12 | gp140+IgG+ | 3-23*01 | 1-26*01 | 3*02 | 14.3 | 17 | λ2-11*01 | λ1*01 | 7.1 | 12 | |
| HIV074 | KS74-11 | gp140+SCC | 1-69*13 | 3-3*01 | 6*03 | 14.3 | 12 | κ1-5*03 | κ2*02 | 7.7 | 10 |