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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Nat Commun. 2015 Apr 24;6:6910. doi: 10.1038/ncomms7910

Figure 5. Isl1 is hypermethylated in mammary tumors.

Figure 5

a, Genome-scale distribution of DMRs identified in mammospheres of normal mammary stem cells and tumorospheres of tumor-initiating cells prepared from MMTV-Neu-Tg mice (n=3 mice in each). b, Cluster analysis of top 100 hypermethylated and few hypomethylated genes. c, Genome browser shot showing ChIP-Seq tracks for H3K27me3 (red) and H3K4me3 (green) levels near Isl1 in embryonic stem cells (ESCs), MaSCs, and luminal progenitors (LPs). d, UCSC genome browser screenshot showing DNA methylation profile at ISL1 locus in mammospheres and tumorospheres. Red and green colors indicate methylated and unmethylated CpG sites, respectively.