Table 3.
Indicators of immunogenic potency and intensity of immunity in BALB/c mice vaccinated with nlpD mutants of Y. pestis strains 231, I-3455, and I-2359
| Immunizing strain of Y. pestis | ImD50, CFU | Immunity index | |
|---|---|---|---|
| LD50 upon challenging with Y. pestis 231, CFU |
II | ||
| 231ΔnlpD | 1.3 × 102 (5.3 × 10 ÷ 3.4 × 102) |
3.9 × 108 (too large) |
7.1 × 107 |
| I-3455ΔnlpD | 2.9 × 102 (1.2 × 102 ÷ 7.5 × 102) |
2.5 × 107(1 × 107 ÷ 3.9 × 108) | 4.5 × 107 |
| I-2359ΔnlpD | 1.1 × 104 (4.4 × 103 ÷ 2.8 × 104) |
2.5 × 103 (6.3 × 102 ÷ 3.9 × 103) |
4.5 × 102 |
| EV NIIEG | 7.5 × 103 (2.4 × 103 ÷ 5.9 × 104) |
1.0 × 103 (2.5 × 102 ÷ 3.9 × 103) |
1.8 × 102 |