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editorial

. 2015 Apr 27;6:126. doi: 10.3389/fphys.2015.00126

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Copyright © 2015 Thinnes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Highly schematic two-dimensional projections of human type-1 VDAC summarising e data from my own lab and the laboratories of Vito De Pinto, Roland Benz, Varda Shoshan-Barmatz, Carmen Mannella, and Jeff Abramson for details see Thinnes, 2015. Fully closed state and open state of native VDAC-1 are compared. Noteworthy the GxxxG motif, that has been shown to work as an ATP binding site and may putatively figure as a peptide interaction/membrane perturbation motif.