Fig. 3.

Retrieving information for the WNT signaling pathway. (a) Genes in four WNT signaling pathways annotated by the Cancer Cell Map, KEGG, PID and Reactome databases, respectively are visualized as four single binary tracks. (b) A Venn diagram comparison of the WNT signaling pathways annotated by the Cancer Cell Map, KEGG and PID databases identified 34 common genes. (c) Among these common genes, 33 genes form a connected protein-protein interaction network that covers the well-known components of the WNT signaling pathway. The omics snapshot (d) and the CRC cell line specific essential gene track (e) depict CRC related molecular alterations and CRC dependency of these 34 genes