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Sera from mice immunized with MS2 displaying N-terminal L2 peptides bind to heterologous HPV peptides. Mice (five per group) were immunized three times and the resulting sera was diluted 1:160 and analyzed by ELISA as in Figure 3a. Bars indicate group means and error bars indicate standard deviations. Means of MS2-31L2 and MS2-16/31L2 groups were analyzed by two-way ANOVA with Bonferroni multiple comparisons. * indicates p < 0.05; *** indicates p < 0.001; ns, not significant.
