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. Author manuscript; available in PMC: 2015 Apr 27.
Published in final edited form as: Nat Methods. 2014 Aug;11(8):801–807. doi: 10.1038/nmeth.3027

Figure 4. Sequence–function maps of proteins important in disease.

Figure 4

A hypothetical cancer cell is shown; mutations in drug transporters, drug metabolic enzymes, transcription factors, and signaling proteins all have the capacity to influence the effectiveness of treatment. Deep mutational scanning of cancer-related proteins could revolutionize our understanding of the consequences of mutations in these proteins and enable genomic medicine.