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. Author manuscript; available in PMC: 2015 Apr 27.
Published in final edited form as: Adv Mater. 2011 Oct 26;23(45):5415–5418. doi: 10.1002/adma.201103046

Figure 1.

Figure 1

Cell culture substrates presenting a heparin-binding peptide sequester heparin from serum and, in turn, amplify recombinant growth factor activity. A) 3-D rendition of a heparin tetrasaccharide (red) binding to HEPpep, which is derived from FGF-2 (HEPpep is green, the rest of the FGF-2 protein is blue). PDB accession number 1BFB. B) A SAM presenting a heparin-binding peptide (green) sequesters a growth factor (blue) in the presence of serum-borne heparin (red), and presents the growth factor to cell surface receptors, resulting in amplified growth factor activity.