Table 2.

The Sepsis Six and Red Flag Sepsis, clinical tools from the UK Sepsis Trust

Sepsis Six	Red Flag Sepsis
1 High-flow oxygen	Systolic BP <90 mmHg or MAP <65 mmHg
2 Blood cultures and consider source control	Lactate >2 mmol/L
3 Intravenous antibiotics	Heart rate >130 per minute
4 Intravenous fluid resuscitation	Respiratory rate >25 per minute
5 Check hemoglobin and serial lactates	Oxygen saturations <91%
6 Hourly urine output measurement	Responds only to voice or pain/unresponsive
	Purpuric rash
An immediate care bundle to be delivered within one hour for patients with sepsis	A risk stratification tool for patients with possible sepsis