Table 5.
Self-paced tapping: mean (95% CI) difference between controls and each patient group, with and without adjustment for age and gender.
| Estimate (95% CI) | bvFTD (N=19) | svPPA (N=9) | naPPA (N=4) | AD (N=8) | |
|---|---|---|---|---|---|
| Clock variance (ms2) | Unadjusted | 11,688 (3821, 29,119) | −506 (−2954, 1608) | 71,150 (−782, 282,794) | 12,365 (−1519, 39,648) |
| Adjusted | 8307 (−11,237, 28,371) | −2274 (−29,423, 2917) | 70,585 (−1836, 288,526) | 9093 (−9676, 33,592) | |
| Motor variance (ms2) | Unadjusted | −290 (−3122, 6541) | −433 (−1041, 104) | −10,868 (−45,649, 1588) | −2606 (−8722, 558) |
| Adjusted | 226 (−3265, 6978) | −353 (−1720, 2782) | −11,002 (−46,602, 1640) | −2260 (−8029, 1365) | |
| Total variance (ms2) | Unadjusted | 11,109 (2298, 28,001) | −1372 (−2972, 82) | 49,414 (968, 191,580) | 7154 (−579, 21,413) |
| Adjusted | 8758 (−5382, 26,617) | −2979 (−20,101, 706) | 48,580 (292, 195,303) | 4573 (−7900, 17,816) | |
| Accuracy (ms) | Unadjusted | −145 (−305, 7) | −126 (−297, 35) | −37 (−199, 172) | −86 (−335, 106) |
| Adjusted | −175 (−360, −26) | −130 (−305, 40) | −28 (−192, 374) | −106 (−389, 76) | |
| Continual drift (across time, ms) | Unadjusted | −101 (−277, 95) | −40 (−183, 83) | 41 (−109, 276) | −163 (−586, 62) |
| Adjusted | −77 (−268, 175) | −4 (−155, 149) | 72 (−137, 426) | −120 (−520, 102) | |
| Drift (absolute value, ms) | Unadjusted | 144 (29, 282) | −28 (−105, 95) | −39 (−138, 83) | 142 (−17, 532) |
| Adjusted | 168 (38, 322) | −21 (−118, 106) | −42 (−140, 69) | 160 (14, 580) |
A positive effect is indicative of greater variance (clock and motor variance) or slower time (accuracy and drift metrics) relative to controls. Effects in bold indicate statistically significant mean differences between the patient group and controls, p<0.05.
Abbreviations: CI, confidence interval; bvFTD, behavioural variant frontotemporal dementia; naPPA, progressive non-fluent aphasia; svPPA, semantic variant primary progressive aphasia, AD, Alzheimer׳s disease.