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. Author manuscript; available in PMC: 2015 Apr 27.
Published in final edited form as: J Natl Cancer Inst. 2008 May 27;100(11):784–795. doi: 10.1093/jnci/djn157

Figure 4.

Figure 4

Schematic diagram of alterations in 60 metastatic melanoma tissue specimens. The genomic region is shown at the top of the diagram. Multiplex ligation-dependent probe analysis (MLPA) probes are indicated with orange-filled rectangles, microsatellite markers with blue-filled rectangles, and exons with green-filled rectangles. Circles are located at each site that was tested. A black circle corresponds to a homozygous deletion, gray circle to a hemizygous loss, and an open circle to no loss. Samples in which the ARF or p16 promoter sequences were methylated are shown with a blue box around the circle corresponding to the relevant exon. Exons with mutations are shown as a red box around the relevant circle. Noninformative microsatellite marker results are shown as a circle with a central black square. Samples that failed MLPA analysis were those in which the corresponding normal samples showed a standard deviation of > 0.29 % among the wild-type control probes. These samples are shown as a circle with an “X”.