. Author manuscript; available in PMC: 2015 Apr 27.

Published in final edited form as: J Natl Cancer Inst. 2008 May 27;100(11):784–795. doi: 10.1093/jnci/djn157

Table 2. Mutations in p16 and ARF detected in a set of 60 human melanomas^*,^†.

Nucleotide	Amino acid change(s) in p16	Amino acid change in ARF	Previous report in somatic cells	Previous report in germline cells
c.43_46del4^‡	All downstream of Asp14	None	Caldas, 1994 (36)	None
c.143C>T	Pro48Leu	None	Gretarsdottir, 1998 (37)	Platz, 1997 (8)
c.172C>T	Arg58Stop	Pro72Leu	Cairns, 1994 (38)	Hussussian, 1994 (26)
c.238C>T	Arg80Stop	Pro94Leu	Gruis, 1995 (39)	None
c.242C>A	Pro81His	Arg96Ser	None	None

C = cytosine; T = thymine; A = adenine; Pro = proline; Leu = leucine; Arg = arginine; His = histidine; Ser = serine

^†

Also identified but not included were a silent mutation, c.387C>T, in p16 and not affecting ARF (n = 1), and the c.442G>A (Ala148Thr) polymorphism (n = 10). ARF amino acids are from Stott et al. (35).

^‡

Sequence for the c.43_46del4 microdeletion identified in p16 exon 1α reads 5′-TGGCTGGC-3′. It can alternately be described as c.47_50del4. Sequence alteration results in a frameshift.

Table 2. Mutations in p16 and ARF detected in a set of 60 human melanomas*,†.

Table 2. Mutations in p16 and ARF detected in a set of 60 human melanomas^*,^†.