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. Author manuscript; available in PMC: 2015 Apr 27.
Published in final edited form as: J Natl Cancer Inst. 2008 May 27;100(11):784–795. doi: 10.1093/jnci/djn157

Table 4. Genetic and epigenetic alterations to the ARF and p16 loci in the entire cohort (n = 60).

Genetic and epigenetic alterations ARF locus p16 locus
None 10 16
One hit
 Hemizygous deletion 14 17
 Promoter methylation 10 14
 Total one hit 24 31
Two hits
 Homozygous deletion 7 5
 Hemizygous loss plus promoter methylation 19 3
 Hemizygous loss plus mutation 0 5
 Total two hits 26 13