Table 5.
Diagnostic parameter | On prediction set (95% CI) (n=1,054) |
On validation set (95% CI) (n=454) |
---|---|---|
Sensitivity | 79.0% (75.3–82.4%) | 75.5% (69.1–81.2%) |
Specificity | 72.2% (68.1–76.1%) | 70.3% (64.2–76.0%) |
PPV | 74.8% (71.0–78.3%) | 68.3% (61.8–74.2%) |
NPV | 76.7% (72.7–80.4%) | 77.2% (71.2–82.6%) |
Positive LR | 2.84 (2.46–3.29) | 2.54 (2.07–3.13) |
Negative LR | 0.29 (0.24–0.35) | 0.35 (0.27–0.45) |
Disease prevalence | 51.1% (48.0–54.2%) | 45.8% (41.2–50.5%) |
Kappa statistics | 0.519 (P<0.001) | 0.454 (P<0.001) |
Abbreviations: CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; LR, likelihood ratio.