Table 2.
Geometric mean comparison of persistent organic pollutant by fibroid status, the ENDO Study operative cohort, 2005–2009 (n=473).
| % > LOD* | Omental Fat | p-value | % > LOD* | Serum | p-value | |||
|---|---|---|---|---|---|---|---|---|
| Geometric mean (95% CI)** | Geometric mean (95% CI)** | Geometric mean (95% CI)** | Geometric mean (95% CI)** | |||||
| Fibroids (n=99) | None (n=374) | Fibroids (n=99) | None (n=374) | |||||
|
|
||||||||
| HCB (ng/g) | 100 | 7.72 (6.44, 9.26) | 6.90 (6.26, 7.62) | 0.11 | 68 | 1.86 (1.35, 2.57) | 2.96 (2.61, 3.36) | 0.12 |
| γ-HCH (ng/g) | 88 | 0.23 (0.19, 0.28) | 0.20 (0.18, 0.22) | 0.07 | 33 | 1.24 (0.93, 1.65) | 0.94 (0.83, 1.07) | 0.07 |
| β-HCH (ng/g) | 88 | 0.27 (0.20, 0.36) | 0.20 (0.18, 0.23) | 0.05 | 36 | 1.33 (1.00, 1.79) | 1.00 (0.88, 1.14) | 0.08 |
| p,p′-DDT (ng/g) | 93 | 1.61 (1.07, 2.42) | 0.68 (0.55, 0.84) | <0.01 | 12 | 1.20 (0.89, 1.62) | 1.22 (1.04, 1.43) | 0.92 |
| o,p′-DDE (ng/g) | 93 | 0.20 (0.15, 0.27) | 0.15 (0.13, 0.17) | 0.09 | 21 | 0.61 (0.47, 0.80) | 0.69 (0.59, 0.79) | 0.90 |
| p,p′-DDE (ng/g) | 100 | 187.43 (146.62, 239.61) | 98.91 (88.11, 111.04) | <0.01 | 99 | 36.95 (29.09, 46.94) | 16.90 (15.31, 18.66) | <0.01 |
| Chlordanes (ng/g) | ||||||||
| trans-chlordane | 67 | 0.12 (0.09, 0.15) | 0.13 (0.11, 0.14) | 0.49 | 27 | 0.49 (0.36, 0.67) | 0.74 (0.62, 0.89) | 0.26 |
| cis-chlordane | 88 | 0.32 (0.26, 0.40) | 0.21 (0.19, 0.24) | <0.01 | 14 | 0.39 (0.28, 0.57) | 0.67 (0.55, 0.82) | 0.38 |
| cis-nonachlor | 93 | 0.47 (0.35, 0.64) | 0.32 (0.28, 0.36) | 0.01 | 1 | 0.49 (0.38, 0.64) | 0.51 (0.44, 0.59) | 0.78 |
| trans-nonachlor | 99 | 9.63 (7.89, 11.75) | 5.15 (4.57, 5.80) | <0.01 | 17 | 0.58 (0.43, 0.79) | 0.52 (0.44, 0.63) | 0.78 |
| oxychlordane | 100 | 8.28 (7.04, 9.74) | 4.50 (4.02, 5.05) | <0.01 | 5 | 0.64 (0.47, 0.88) | 0.69 (0.57, 0.83) | 0.52 |
| PBDEs (ng/g) | ||||||||
| PBDE 47 | 100 | 23.14 (17.75, 30.15) | 24.40 (21.46, 27.76) | 0.27 | 93 | 6.03 (4.67, 7.78) | 6.86 (6.16, 7.62) | 0.51 |
| PBDE 99 | 76 | 0.80 (0.36, 1.78) | 0.97 (0.65, 1.45) | 0.65 | 91 | 3.36 (2.73, 4.12) | 3.51 (3.17, 3.88) | 0.85 |
| PBDE 100 | 83 | 1.21 (0.57, 2.55) | 1.77 (1.23, 2.54) | 0.57 | 79 | 1.77 (1.50, 2.08) | 1.91 (1.75, 2.08) | 0.83 |
| PBDE 153 | 91 | 6.13 (3.81, 9.86) | 4.86 (3.52, 6.71) | 0.56 | 94 | 2.66 (2.18, 3.23) | 3.62 (3.32, 3.94) | 0.01 |
| PBDE 154 | 41 | 0.13 (0.06, 0.28) | 0.11 (0.07, 0.15) | 0.21 | 63 | 0.90 (0.72, 1.13) | 1.17 (1.05, 1.30) | 0.02 |
| PBDE 183 | 32 | 0.14 (0.06, 0.33) | 0.09 (0.06, 0.14) | 0.08 | 7 | 0.52 (0.50, 0.54) | 0.53 (0.52, 0.54) | 0.65 |
| PBDE 209 | 92 | 2.19 (1.53, 3.15) | 2.55 (2.16, 3.01) | 0.41 | 94 | 15.12 (10.31, 22.18) | 8.75 (7.32, 10.46) | 0.01 |
| PCBs (ng/g) | ||||||||
| PCB 18 | 53 | 0.13 (0.09, 0.18) | 0.13 (0.10, 0.15) | 0.62 | 41 | 5.97 (3.73, 9.56) | 3.43 (2.61, 4.51) | 0.04 |
| PCB 28 | 63 | 0.28 (0.18, 0.43) | 0.20 (0.16, 0.24) | 0.18 | 57 | 4.17 (2.90, 5.99) | 2.89 (2.32, 3.61) | 0.05 |
| PCB 44 | 67 | 0.18 (0.13, 0.27) | 0.07 (0.06, 0.09) | <0.01 | 55 | 4.27 (3.01, 6.06) | 2.37 (1.93, 2.90) | 0.01 |
| PCB 49 | 63 | 0.07 (0.05, 0.08) | 0.06 (0.05, 0.07) | 0.25 | 55 | 2.61 (1.91, 3.57) | 1.52 (1.26, 1.83) | <0.01 |
| PCB 52 | 63 | 0.06 (0.05, 0.08) | 0.06 (0.05, 0.07) | 0.24 | 56 | 6.15 (4.26, 8.89) | 5.14 (4.15, 6.38) | 0.01 |
| PCB 66 | 71 | 0.08 (0.07, 0.10) | 0.07 (0.06, 0.08) | 0.05 | 55 | 7.70 (5.18, 11.45) | 3.96 (3.09, 5.09) | <0.01 |
| PCB 74 | 93 | 2.18 (1.54, 3.08) | 1.01 (0.81, 1.26) | <0.01 | 47 | 2.36 (1.64, 3.39) | 1.68 (1.35, 2.08) | 0.02 |
| PCB 87 | 68 | 0.07 (0.06, 0.09) | 0.06 (0.05, 0.07) | 0.37 | 48 | 1.82 (1.29, 2.57) | 1.51 (1.21, 1.88) | <0.01 |
| PCB 99 | 99 | 2.33 (1.93, 2.80) | 1.13 (1.01, 1.26) | <0.01 | 53 | 2.03 (1.45, 2.84) | 1.39 (1.14, 1.68) | <0.01 |
| PCB 101 | 91 | 0.26 (0.19, 0.34) | 0.19 (0.17, 0.22) | 0.03 | 54 | 5.48 (3.72, 8.07) | 4.27 (3.38, 5.40) | 0.02 |
| PCB 118 | 99 | 2.69 (2.08, 3.47) | 1.59 (1.39, 1.82) | <0.01 | 50 | 4.46 (3.17, 6.27) | 3.46 (2.71, 4.43) | <0.01 |
| PCB 128 | 74 | 0.12 (0.10, 0.15) | 0.09 (0.08, 0.10) | <0.01 | 27 | 0.61 (0.41, 0.89) | 0.52 (0.41, 0.65) | 0.01 |
| PCB 138 | 100 | 9.07 (7.65, 10.75) | 4.53 (4.08, 5.03) | <0.01 | 75 | 5.31 (4.24, 6.64) | 3.55 (3.04, 4.13) | <0.01 |
| PCB 146 | 96 | 1.24 (0.99, 1.56) | 0.46 (0.39, 0.53) | <0.01 | 39 | 0.79 (0.63, 1.01) | 0.64 (0.54, 0.76) | 0.10 |
| PCB 149 | 73 | 0.09 (0.07, 0.11) | 0.06 (0.06, 0.07) | <0.01 | 44 | 2.17 (1.42, 3.32) | 1.91 (1.52, 2.40) | 0.06 |
| PCB 151 | 70 | 0.08 (0.07, 0.10) | 0.06 (0.05, 0.07) | <0.01 | 38 | 1.24 (0.94, 1.65) | 0.97 (0.81, 1.16) | <0.01 |
| PCB 153 | 100 | 12.74 (10.73, 15.11) | 5.98 (5.38, 6.65) | <0.01 | 69 | 4.07 (3.19, 5.20) | 2.86 (2.42, 3.39) | <0.01 |
| PCB 156 | 80 | 1.03 (0.69, 1.52) | 0.32 (0.25, 0.41) | <0.01 | 0 | 0.25 (0.23, 0.28) | 0.27 (0.26, 0.28) | <0.01 |
| PCB 157 | 77 | 0.11 (0.09, 0.13) | 0.08 (0.07, 0.09) | <0.01 | 0 | 0.25 (0.23, 0.28) | 0.27 (0.26, 0.28) | <0.01 |
| PCB 167 | 72 | 0.17 (0.13, 0.22) | 0.09 (0.07, 0.10) | <0.01 | 1 | 0.28 (0.24, 0.34) | 0.28 (0.27, 0.30) | 0.01 |
| PCB 170 | 99 | 3.23 (2.65, 3.92) | 1.51 (1.30, 1.75) | <0.01 | 49 | 1.03 (0.82, 1.30) | 0.80 (0.70, 0.92) | <0.01 |
| PCB 172 | 96 | 0.42 (0.33, 0.54) | 0.22 (0.19, 0.25) | <0.01 | 50 | 1.37 (1.06, 1.76) | 0.98 (0.86, 1.12) | 0.05 |
| PCB 177 | 94 | 0.50 (0.40, 0.63) | 0.23 (0.20, 0.26) | <0.01 | 16 | 0.46 (0.36, 0.60) | 0.42 (0.38, 0.47) | 0.17 |
| PCB 178 | 95 | 0.66 (0.52, 0.83) | 0.28 (0.24, 0.33) | <0.01 | 10 | 0.38 (0.33, 0.44) | 0.33 (0.31, 0.36) | 0.67 |
| PCB 180 | 100 | 7.85 (6.43, 9.58) | 4.08 (3.59, 4.64) | <0.01 | 49 | 2.20 (1.62, 2.99) | 2.08 (1.78, 2.43) | 0.17 |
| PCB 183 | 98 | 1.10 (0.88, 1.36) | 0.48 (0.41, 0.56) | <0.01 | 23 | 0.61 (0.50, 0.73) | 0.46 (0.41, 0.51) | <0.01 |
| PCB 187 | 100 | 2.87 (2.41, 3.41) | 1.43 (1.26, 1.62) | <0.01 | 54 | 1.44 (1.15, 1.80) | 1.10 (0.96, 1.26) | 0.01 |
| PCB 189 | 85 | 0.12 (0.10, 0.14) | 0.09 (0.08, 0.10) | <0.01 | 1 | 0.26 (0.22, 0.31) | 0.27 (0.26, 0.29) | <0.01 |
| PCB 194 | 90 | 0.95 (0.66, 1.35) | 0.36 (0.29, 0.44) | <0.01 | 3 | 0.31 (0.22, 0.44) | 0.37 (0.31, 0.43) | <0.01 |
| PCB 195 | 90 | 0.28 (0.22, 0.36) | 0.17 (0.15, 0.20) | <0.01 | 17 | 0.63 (0.44, 0.91) | 0.40 (0.34, 0.48) | 0.34 |
| PCB 196 | 98 | 1.59 (1.30, 1.95) | 0.68 (0.59, 0.79) | <0.01 | 19 | 0.54 (0.43, 0.66) | 0.39 (0.35, 0.44) | 0.74 |
| PCB 201 | 84 | 0.11 (0.09, 0.15) | 0.11 (0.09, 0.12) | 0.46 | 9 | 0.44 (0.26, 0.74) | 0.71 (0.54, 0.92) | 0.01 |
| PCB 206 | 89 | 0.91 (0.70, 1.18) | 0.36 (0.31, 0.43) | <0.01 | 33 | 0.40 (0.30, 0.53) | 0.48 (0.42, 0.56) | 0.06 |
| PCB 209 | 83 | 0.39 (0.31, 0.50) | 0.22 (0.19, 0.26) | <0.01 | 21 | 0.46 (0.35, 0.61) | 0.39 (0.32, 0.46) | 0.81 |
| PFCs (ng/g) | ||||||||
| PFOS | -- | -- | -- | -- | 100 | 5.90 (5.16, 6.74) | 6.71 (6.22, 7.23) | 0.04 |
| PFOA | -- | -- | -- | -- | 99 | 2.24 (1.99, 2.52) | 2.37 (2.19, 2.55) | 0.11 |
| PFNA | -- | -- | -- | -- | 97 | 0.60 (0.53, 0.69) | 0.63 (0.58, 0.68) | 0.18 |
| PFDA | -- | -- | -- | -- | 84 | 0.19 (0.16, 0.21) | 0.18 (0.17, 0.20) | 0.79 |
| PFHxS | -- | -- | -- | -- | 97 | 0.37 (0.32, 0.43) | 0.47 (0.43, 0.51) | 0.01 |
| PFHpA | -- | -- | -- | -- | 34 | 0.05 (0.03, 0.06) | 0.06 (0.05, 0.06) | 0.21 |
| PFUNDA | -- | -- | -- | -- | 39 | 0.09 (0.07, 0.11) | 0.05 (0.05, 0.06) | <0.01 |
| PFDoDA | -- | -- | -- | -- | 3 | 0.02 (0.02, 0.03) | 0.02 (0.02, 0.02) | 0.67 |
| PFOSA | -- | -- | -- | -- | 0 | 0.02 (0.02, 0.03) | 0.02 (0.02, 0.02) | 0.05 |
| Fat lipid content (ng/g) | 100 | 77.70 (74.53, 81.00) | 80.87 (79.36, 82.40) | 0.10 | ||||
| Serum total cholesterol (ng/g) | 100 | 179.66 (174.24, 185.25) | 177.46 (173.95, 181.05) | 0.58 | ||||
| Serum triglycerides (ng/g) | 100 | 123.77 (110.85, 138.18) | 126.588 (120.73, 132.73) | 0.54 | ||||
*
For PFCs percent above LOQ reported
**
Geometric means and corresponding 95% confidence intervals were adjusted for lipid (total fat lipid or serum lipids#).
#Serum lipid = (serum total cholesterol × 2.27) + serum triglycerides + 62.3.