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Domain structure and organization of ADAMTS-18. ADAMTS-18 consists of a signal peptide, prodomain, metalloprotease domain, disintegrin domain, the first thrombospondin type 1 repeat (TSP1), Cys-rich domain, spacer domain and 5 additional TSP1 repeats. Notably, the intact molecular weight (WM) of ADAMTS-18 is 135KD.
