Table 2.
Dysregulated miRNAs and effect on p53 pathway
| Targeted Transcription Factors in p53 Pathway |
Net Effect on the p53 Tumor Suppressor Pathway | |||||||
|---|---|---|---|---|---|---|---|---|
| MicroRNA | Change in CRC progression | Target 1 | Target 2 | Target 3 | Target 4 | Net Effect 1 | Net Effect 2 | Net Effect 3 |
| miR-372 | Down-regulation in CRC progression in ALL IBD patients |
P21Cip1 | Not applicable | Promotion of cell cycle progression |
Inhibition of cell cycle arrest |
Not applicable | ||
| miR-17 | Up-regulation from non-neoplasia to dysplasia in CD |
PCAF | SIRT | P63 | E2F1 | Inhibition of cell cycle progression |
Inhibition of cell cycle arrest |
Inhibition of apoptosis |
| let-7e | Up-regulation from non-neoplasia to dysplasia in CD |
E2F1 | Not applicable | Inhibition of apoptosis | Not applicable | |||
| miR-122 | Up-regulation from non-neoplasia to dysplasia in CD |
GSK-3B | Beta- catenin |
Cyclin G | N/A | Inhibition of cell cycle arrest |
Not applicable | |
| miR-214 | Up-regulation in UC cancer vs. CD cancer |
PTEN | Not applicable | Inhibition of tumor suppression |
Not applicable | |||
| miR-15b | Down-regulation in CD cancer vs. UC cancer |
BCL2 | Not applicable | Promotion of cell survival | Not applicable | |||
*
The above listed microRNAs are found to be significantly dysregulated (p<0.001) and with FDR <0.10