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. 2015 Apr 22;10:3081–3095. doi: 10.2147/IJN.S79550

Figure 6.

Figure 6

In vivo antitumor study in BALB/c mice implanted with HeLa cells.

Notes: (A) Body weight changes in control mice and those treated with UV laser only, VCR, VGC-L, and VGC-L plus UV laser (n=5). **P<0.01. (B) Relative tumor volume in control mice and those treated with UV laser only, VCR, VGC-L, and VGC-L plus UV laser (n=5). *P<0.05, **P<0.01. (C) Photographs of tumors after excision from (a) control; (b) only UV laser; (c) VCR; (d) VGC-L; and (e) VGC-L plus UV laser groups. (D) TUNEL staining of the isolated tumor tissue from (a) control; (b) blank plus UV laser; (c) VCR; (d) VGC-L; and (e) VGC-L plus UV laser groups. The apoptotic cells and cell nuclei were stained green and blue, respectively.

Abbreviation: VCR, vincristine sulfate; VGC-L, vincristine sulfate-gold nanoparticles conjugates loaded liposomes; TUNEL, Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling.