Table 4. Autonomic neuropathy parameters of acromegalic patients and age-matched control subjects.

	Control	Acromegaly
Heart rate variation during deep breathing (1/min)	17.20 ± 6.44	14.00 ± 7.22
Valsalva ratio	1.70 ± 0.34	1.40 ± 0.28*
30/15 ratio	1.20 ± 0.18	1.10 ± 0.21*
Systolic BP fall after standing up (mm Hg)	6.40 ± 6.77	9.10 ± 9.66
Diastolic BP increase after sustained handgrip (mm Hg)	20.00 ± 9.22	17.50 ± 8.2
AN score	1.50 ± 1.28	2.90 ± 2.11*

Abbreviations: AN, autonomic neuropathy; BP, blood-pressure; 30/15 ratio, immediate heart rate response to standing; n = 30 in each group,

*P<0.05

**P<0.001 vs controls.