Table 1. Clot formation and thrombin generation parameters.
| mM cystamine | |||||
|---|---|---|---|---|---|
| 0 | 1 | 10 | 50 | 100 | |
| Clot Formation | |||||
| Onset (minutes) | 4.6±1.5 | 4.8±1.4 | 5.4±2.2 | 10.0±2.8* | >60* |
| Rate (mOD/minute) | 54.3±32.1 | 67.5±23.2 | 64.7±31.4 | 69.6±35.6 | 0* |
| Peak turbidity change | 0.63±0.02 | 0.64±0.05 | 0.64±0.03 | 0.51±0.09* | 0* |
| Thrombin Generation | |||||
| Lag time (minutes) | 4.0±1.2 | 4.5±2.0 | 5.1±2.2 | 7.1±2.6 | 10.1±0.8* |
| Time to peak (minutes) | 8.4±1.8 | 8.8±2.5 | 10.3±3.2 | 12.2±3.5 | 19.9±0.2* |
| Thrombin peak (nM) | 97.3±38.0 | 62.2±25.9 | 18.8±9.2* | 26.9±5.9* | 5.1±1.8* |
| Endogenous thrombin potential (nM.minutes) | 934.4±213.9 | 667.6±123.7* | 277.3±108.1* | 367.0±75.4* | 107.3±28.6* |
Mean ± standard deviation
*P<0.05 vs 0 mM cystamine (untreated plasma)