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. Author manuscript; available in PMC: 2015 Apr 27.
Published in final edited form as: Physiol Rev. 2012 Apr;92(2):635–688. doi: 10.1152/physrev.00008.2011

Figure 7. Actions of TSP-2 in the remodeling myocardium.

Figure 7

Experimental evidence using loss-of-function approaches suggests an important role for TSP-2 in protection of the aging, infarcted and pressure-overloaded heart. TSP-2 null mice develop dilative cardiomyopathy; this may be due to loss of CD47/integrin-mediated pro-survival signals in cardiomyocytes. TSP-2 absence is also associated with cardiac rupture and heart failure in models of myocardial infarction and angiotensin-II-mediated hypertrophy. TSP-2 may protect the remodeling heart by mediated essential actions on assembly and organization of the cardiac matrix, by inhibiting MMP activity, by activating pro-survival signals on cardiomyocytes, or by suppressing inflammation.