Fig 1. Difference from core and folding nucleus of the immunoglobulin-like fold, redrawn from results established by the group of Jane Clarke.

A) The core corresponds to the CATH code domain 2ck2A00 [28]; in red peripheral core residues, in cyan I8 and F92 and in blue the rest of the core. B) The nucleus according to Clarke’s numbering (I20 in red, Y36 in green, I59 in yellow and V70 in cyan) for the CATH code domain 1tenA00 [19].