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5-FU and uracil are inactivated by dihydropyrimidine dehydrogenase to fluoro-5,6-dihydrouracil and 5,6-dihydrouracil, respectively, which are subsequently converted by dihydropyrimidinase to fluoro-β-ureidopropionate and β-ureidopropionate, respectively. Fluoro-β-alanine and β-alanine are the final catabolite in this cascade and are formed by β-ureidopropionase.
