Table 2. Primaquine-induced endovesiculation.

primaquine concentration	genotype	% endovesiclesmean ± stdev.	F(2,79)	p-value
0,75mM	homozygous	5,16 ± 3,29	2,25	0,112
	heterozygous	6,29 ± 3,50
	wild-type	7,34 ± 3,54
1,50mM	homozygous	20,07 ± 7,06	1,66	0,197
	heterozygous	21,18 ± 9,67
	wild-type	24,51 ± 8,10
2,00mM	homozygous	20,25 ± 9,23	1,02	0,364
	heterozygous	21,77 ± 9,50
	wild-type	24,58 ± 12,46
3,00mM	homozygous	56,90 ± 13,01	1,41	0,251
	heterozygous	60,75 ± 13,83
	wild-type	63,23 ± 10,70

Drug induced endovesiculation was assayed for blood samples of donors that are homozygous (n = 23), heterozygous (n = 36) and wild-type (n = 22) with respect to the c.680 A>G mutation in the PANK2 gene as described in the Material and Methods section using 0.75, 1.5, 2.0 and 3.0 mM primaquine. Mean values and the statistical significance of the difference between the three groups (assessed by an oneway ANOVA) are given.