Table 3. TNFA, IFNG and TNFRSF1A gene polymorphisms in CD.
| Gene | dbSNP | MAF a | Genotypes | Cases b | Controls c | Dominant model | Recessive model | ||
|---|---|---|---|---|---|---|---|---|---|
| n (freq) | n (freq) | p-value (2df) | OR d (95%CI) | p-value (2df) | OR d (95%CI) | ||||
| TNFA | -1031T>C | C (0.027) | C/C | 9 (0.04) | 22 (0.08) | 0.027 | 0.65(0.44–0.95) | 0.042 | 0.41 (0.17–0.97) |
| T/C | 73 (0.30) | 97 (0.36) | |||||||
| T/T | 162 (0.66) | 148 (0.56) | |||||||
| -857C>T | T (0.153) | T/T | 3 (0.01) | 8 (0.03) | <0.0001 | 0.42 (0.27–0.65) | 0.316 | 0.48 (0.12–2.01) | |
| C/T | 45 (0.19) | 89 (0.33) | |||||||
| C/C | 196 (0.8) | 170 (0.64) | |||||||
| -376G>A | A (0.047) | A/A | 2 (0.01) | 0 (-) | 0.023 | 2.25 (1.12–4.51) | - | - | |
| G/A | 28 (0.11) | 16 (0.06) | |||||||
| G/G | 214 (0.88) | 251 (0.94) | |||||||
| -308G>A | A (0.216) | A/A | 20 (0.08) | 3 (0.01) | <0.0001 | 4.76 (3.12–7.26) | 0.001 | 10.09 (2.71–37.55) | |
| G/A | 117 (0.48) | 58 (0.22) | |||||||
| G/G | 107 (0.44) | 206 (0.77) | |||||||
| -238G>A | A (0.068) | A/A | 2 (0.01) | 1 (0.01) | 0.241 | 1.41 (0.80–2.46) | 0.841 | 1.28 (0.11–14.67) | |
| G/A | 34 (0.14) | 29 (0.11) | |||||||
| G/G | 208 (0.85) | 237 (0.88) | |||||||
| IFNG | +874A>T | T (0.458) | T/T | 52 (0.21) | 56 (0.21) | 0.929 | 0.98 (0.65–1.48) | 0.810 | 1.06 (0.67–1.68) |
| A/T | 116 (0.48) | 136 (0.51) | |||||||
| A/A | 76 (0.31) | 75 (0.28) | |||||||
| TNFRSF1A | c.625+10A>G | A (0.363) | G/G | 17 (0.33) | 26 (0.39) | 0.739 | 1.16 (0.47–2.76) | 0.061 | 0.21 (0.04–1.07) |
| G/A | 32 (0.63) | 31 (0.47) | |||||||
| A/A | 2 (0.04) | 9 (0.14) | |||||||
p values in boldface are significant
aMAF = minor allele frequency
bCases: n = 244; n = 51 for TNFRSF1A
cControls: n = 267; n = 66 for TNFRSF1A
dOR = Odds Ratio; 95%CI = 95% Confidence Intervals. Odds Ratios were calculated by binary logistic regression analysis adjusted for age, gender and H. pylori infection.