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. 2015 Apr 27;10(4):e0123958. doi: 10.1371/journal.pone.0123958

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© 2015 Salm et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — (a) DAOY cells were transfected with siRNA against PIK3CA or PIK3CD and analyzed 48h post transfection for gene down-regulation at mRNA level by real-time PCR and at protein level by Western blot. (b) Heat map representing the expression of PIK3CA and PIK3CD regulated genes. (c) GeneGo Metacore analysis of transcriptional networks. The set of genes deregulated by PIK3CA silencing in DAOY cells were analyzed via GeneGo Metacore software. The most affected network comprising the oncogene c-Myc and some its downstream targets is shown.