. 2015 Apr 27;10(4):e0123980. doi: 10.1371/journal.pone.0123980

Table 5. VOC-concentration ranges and differences in relation to MAP-specific antibody levels and interferon-γ response after stimulation with JPPD.

a) breath	antibody titer (S/P%)							stimulation-index of the JPPD-specific interferon-γ-response
	≥ 51.02			< 51.02				≥ 1.157			< 1.157
measurements	15			19				16			18
percentiles	25%	median	75%	25%	median	75%	p	25%	median	75%	25%	median	75%	p
1-Propanol	182.08	202.26	305.02	221.18	325.37	647.68	0.048	181.29	199.16	279.77	246.43	417.71	669.23	0.01
2-Butanone	0.34	0.40	0.53	0.61	0.75	1.08	<0.001	0.33	0.41	0.54	0.69	0.76	1.12	<0.001
Acetone	18.89	24.11	32.66	28.76	32.70	43.21	0.011	18.53	23.32	30.22	32.11	34.34	46.93	<0.001
Benzene	^†	0.55	0.61	0.59	0.70	0.82	0.012	^†	0.55	0.64	0.59	0.71	0.93	0.009
Butanal. 2-methyl-	^†	0.32	0.45	^†	^†	0.85	0.776	^†	0.35	0.50	^†	^†	0.68	0.83
Ethylbenzene	^†	0.12	0.15	^†	0.14	0.19	0.211	^†	0.11	0.15	^†	0.16	0.20	0.084
Hexanal	0.35	0.41	0.51	0.43	0.50	0.74	0.055	0.36	0.45	0.51	0.37	0.50	0.77	0.128
Nonanal	1.32	1.46	1.71	1.26	2.05	2.50	0.053	1.30	1.45	1.82	1.29	2.07	2.59	0.047
Styrene	0.06	0.16	0.49	0.05	0.15	0.63	0.839	0.08	0.19	0.75	0.04	0.10	0.39	0.183
b) feces	antibody titer (S/P%)							stimulation-index of the JPPD-specific interferon-γ-response
	≥ 51.02			< 51.02				≥ 1.157			< 1.157
measurements	21			21				22			20
percentiles	25%	median	75%	25%	median	75%	p	25%	median	75%	25%	median	75%	p
Pentane^*	11.45	15.11	20.27	11.43	15.79	20.70	0.839^*	12.41	17.67	20.14	11.38	15.54	20.78	0.426^*
Hexane^*	^†	7.99	11.14	^†	^†	9.25	0.221^*	^†	8.12	11.10	^†	^†	9.15	0.07
Heptane^*	6.85	7.45	9.70	6.66	8.04	9.28	0.94	7.02	7.63	10.62	5.86	7.15	8.75	0.073^*
Acetone^*	799.26	1011.08	1305.37	291.71	383.92	501.73	<0.001	744.34	1007.45	1295.41	290.37	370.35	485.57	<0.001
2-Butanone	87.85	125.45	193.84	47.87	62.05	104.01	0.007	68.67	125.14	191.82	46.50	69.65	104.25	0.012
2-Pentanone	347.69	476.16	585.54	209.40	280.80	315.93	<0.001	331.36	479.08	573.15	200.64	281.89	315.15	<0.001
2-Hexanone	139.44	178.42	212.50	61.14	94.08	119.06	<0.001	141.33	178.82	221.09	65.81	91.67	116.33	<0.001
2-Heptanone^*	33.08	38.79	45.64	22.55	26.04	34.42	0.005^*	33.68	38.76	45.86	22.96	25.98	33.81	0.005^*
3-Octanone^*	47.89	56.37	85.87	36.40	56.19	82.12	0.718^*	52.48	59.19	88.40	30.68	49.18	78.29	0.091^*
2-Butanone, 3-methyl-	26.26	32.89	39.74	25.59	36.20	111.90	0.237	26.90	32.65	39.49	23.88	39.79	113.00	0.399
2-Pentatone, 3-methyl-	26.30	34.37	53.09	16.07	19.41	28.06	<0.001	28.42	35.71	62.36	15.97	18.91	25.10	<0.001
Methyl Isobutyl Ketone^*	11.57	13.51	18.23	6.35	9.00	11.36	<0.001^*	12.49	14.64	19.64	6.24	8.76	10.41	<0.001
Isoprene^*	19.87	29.60	37.19	8.92	16.18	22.30	0.009^*	24.37	33.72	37.96	6.85	13.58	20.17	<0.001
Acetic acid, methyl ester^*	46.57	55.47	68.61	49.83	56.22	67.18	0.898^*	44.16	53.06	67.61	51.26	57.65	67.51	0.494^*
Sulfide, dimethyl	409.76	815.52	1099.63	127.23	184.20	258.03	<0.001	377.90	836.66	1158.19	123.61	182.72	241.42	<0.001
Disulfide, dimethyl^*	0.37	1.12	6.44	^†	0.23	0.68	0.005	0.41	1.21	5.72	^†	0.22	0.74	0.005
Furan^*	1.46	1.70	1.79	1.52	1.84	3.22	0.208	1.47	1.72	1.99	1.53	1.82	2.94	0.332
Furan, 2-ethyl-^*	7.43	9.96	11.89	5.26	6.63	7.75	<0.001^*	7.80	9.97	12.30	5.23	6.40	7.50	<0.001
Furan, 2-methyl-^*	14.72	19.98	23.68	12.41	15.23	17.90	0.046^*	15.36	19.78	24.46	12.74	15.15	17.93	0.007^*
Furan, 3-methyl-^*	23.41	32.32	41.93	19.33	21.37	25.66	<0.001	27.69	33.00	43.16	18.63	19.96	24.03	<0.001
Furan, 2-pentyl-^*	21.99	29.25	33.91	23.11	26.73	30.05	0.454^*	24.74	29.45	34.33	20.85	24.64	28.64	0.099^*

p-values from Mann-Whitney-U-tests

^† value lower than limit of detection

* p-values from t-tests