Table 2. Univariate and multivariate Cox proportional hazards model for recurrence-free survival (RFS) and overall survival (OS).
| n (%) | RFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | ||||||
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | ||
| Age | |||||||||
| <70 | 77 (73%) | ||||||||
| ≥70 | 28 (27%) | HR 0.904 (0.455–1.796) | P = 0.773 | HR 1.144 (0.565–2.317) | P = 0.708 | ||||
| Gender | |||||||||
| Female | 12 (11%) | ||||||||
| Male | 93 (89%) | HR 1.239 (0.556–1.866) | P = 0.653 | HR 2.734 (0.656–11.39) | P = 0.167 | ||||
| Smoking history | |||||||||
| Never/former | 79 (75%) | ||||||||
| Current | 26 (25%) | HR 1.096 (0.552–2.176) | P = 0.794 | HR 1.315 (0.648–2.668) | P = 0.448 | ||||
| Histology a | |||||||||
| ADC | 47 (45%) | ||||||||
| SCC | 50 (48%) | HR 0.946 (0.500–1.791) | P = 0.865 | HR 1.268 (0.639–2.518) | P = 0.497 | ||||
| Histological grade | |||||||||
| WD | 12 (12%) | P = 0.766 | P = 0.576 | ||||||
| MD | 45 (46%) | HR 0.722 (0.262–1.984) | P = 0.527 | HR 0.614 (0.218–1.724) | P = 0.354 | ||||
| PD | 42 (42%) | HR 0.877 (0.324–2.373) | P = 0.796 | HR 0.833 (0.305–2.280) | P = 0.723 | ||||
| Stage | |||||||||
| I, II | 92 (84%) | ||||||||
| III, IV | 13 (16%) | HR 2.066 (0.945–4.520) | P = 0.069 | HR 1.877 (0.853–4.134) | P = 0.118 | HR 1.759 (0.722–4.285) | P = 0.214 | HR 1.638 (0.662–4.053) | P = 0.286 |
| SIRT1/SIRT2 | |||||||||
| Others | 72 (71%) | ||||||||
| Both high | 30 (29%) | HR 2.790 (1.150–5.155) | P = 0.001 | HR 2.698 (1.457–4.996) | P = 0.002 | HR 2.280 (1.169–4.449) | P = 0.016 | HR 2.193 (1.118–4.300) | P = 0.022 |
aonly the more frequent histological subtypes, adenocarcinomas (ADC) and squamous cell carcinoma (SCC), were analyzed.
WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated. The values highlighted in bold represent significant differences; HR: Hazard ratio.